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With the use of terms such as "Pacific Rim" to describe cultures oreven economies by the bodies of water they border (or particular physicalfeatures such as plains or mountain ranges) rather than by their continental landmasses and political borders, the term "Mediterranean" has again becomepopular in recent years. Considering that the ancient and early-medieval (pre AD1000) peoples of southern Europe, Asia Minor and northern Africa were raciallysimilar, and also culturally similar in many respects, we prefer to define them asMediterranean rather than European, Asian or African --partly becausebroad geographical definitions (based on continents) had little political meaninguntil "new" places (like America) were "discovered" in thelatter Middle Ages. The "European" Romans scarcely knew of theexistence of the Lapps of northern Scandinavia, a unique ethnic group. Though theEgyptians had contact with Ethiopia, the "African" Carthaginians andSaracens had little, if any, knowledge of the peoples of what is now Zambia. Viathe Persians, the Phoenicians traded with India and even Mongolia, but theyprobably knew nothing of Japanese civilization. Despite political differences,the Romans had more in common with the Carthaginians than with most northernEuropean groups, while the Carthaginians had more in common with the Persiansthan with most sub-Saharan peoples.

Patients with sickle cell anemia can experience recurrent pain episodes, which affect quality of life. The reported prevalence of pain is higher in studies using patient diaries than in healthcare facility utilization data. Determining Effects of Platelet Inhibition on Vaso-Occlusive Events was a multinational study that assessed the efficacy and safety of prasugrel in reducing the rate of vaso-occlusive events in children with sickle cell anemia () and included an electronic patient-reported outcome diary to record pain occurrence. We aimed to capture diary completion rates and compliance in children who used the electronic patient-reported outcome diary during the Determining Effects of Platelet Inhibition on Vaso-Occlusive Events study and examine factors contributing to diary completion rates and compliance.

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The earliest identifiable (pre-historic) "modern human" inhabitantsof Sicily were present at least 10,000 to 12,000 years ago and many lived incaves. People are interested in the physical appearance of their ancestors,whether recent or ancient. For lack of a more descriptive term, the earliestSicilians would be identified as "Caucasoid" in appearance. Generally,they probably had darker hair and eyes than most of their northern-Europeancounterparts, and probably tanned easily. Extant visual evidence (sculpture,mosaics, etc.) and surviving literary accounts indicate that most ancientMediterranean peoples, whether Phoenician, Egyptian, Greek, Roman or Sicanian,were generally a little darker than northern Europeans. Ancient peoples were, onaverage, shorter than modern ones, and did not live as long. Peoples from acrossEurope were drawn (or coerced) to Rome, but it was the Middle Ages that broughtVandals, Vikings and Visigoths to the sunny "Med" in large numbers,literally changing the face of the Mediterranean population. (Even today, whenthere are more blondes in Sicily than in ancient times, Sicilian women joke aboutthe obsession of the local men with foreign blondes, and a black-haired,dark-eyed Sicilian girl is referred to as a "mora," or Moor,while a redhead is a "normanna" or Norman --terms in wide usesince the Middle Ages.) Until the fall of the Roman Empire, there were no knownlarge-scale "non-Mediterranean" incursions into Sicily by sub-Saharanor east-Asian peoples (the Huns come to mind), nor do there appear to have beenany substantial "Nordic" (northern European) colonisations until thearrival of the Longobards and Normans. Rather, the Sicels and Elymians wereMediterranean peoples arriving from regions such as the Italian peninsula or theeastern Mediterranean at some point after 1500 BC, while the Sicanians wereprobably descended from the earliest inhabitants of Sicily. There are fewarcheological differences among the three civilizations and their Iron Agecultures, though the very few known linguistic distinctions, inferred fromGreek-era records and a few stone inscriptions using Phoenician characters, linkthem in some way to particular regions. (In theory, contact with certaincivilizations, rather than colonization per se, may partly explain this;by analogy, many Indians and Chinese speak English but are not descended from theEnglish, and many non-Italic peoples in the Roman Empire spoke Latin, just asmany Romans spoke Greek.) The earliest Sicilians assimilated, and thenamalgamated, with the Phoenicians and Greeks within a few brief centuries. By 300BC, they had ceased to exist as distinct ethnic populations, having becomeHellenized.

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Italy - modern nation (Italian Republic) which includes the Italianpeninsula and the islands of Sicily and Sardinia. (In historical references theterm is often used to describe the Italian peninsula as opposed to the two largeisland regions, but today's Sicilians are Italian.) Italy has existed as a unitedcountry only since 1860, before which time the peoples of this region identifiedthemselves as Milanese, Piedmontese, Sardinians, Venetians, Sicilians, etc.

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Essay/Term paper: Sickle cell anemia


Essay on Biology. Research Paper on Sickle Cell Anemia

IRON DEFICIENCY ANEMIAIn an essay of 500-750 words, explain your answer and include rationale. Are you looking for a similar paper or any other quality academic essay?

Sickle Cell Anemia Definition And Term Paper - 3168 …

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The sickle hemoglobin is an abnormal hemoglobin due to point mutation (GAG → GTG) in exon 1 of the β globin gene resulting in the substitution of glutamic acid by valine at position 6 of the β globin polypeptide chain. Although the molecular lesion is a single-point mutation, the sickle gene is pleiotropic in nature causing multiple phenotypic expressions that constitute the various complications of sickle cell disease in general and sickle cell anemia in particular. The disease itself is chronic in nature but many of its complications are acute such as the recurrent acute painful crises (its hallmark), acute chest syndrome, and priapism. These complications vary considerably among patients, in the same patient with time, among countries and with age and sex. To date, there is no well-established consensus among providers on the management of the complications of sickle cell disease due in part to lack of evidence and in part to differences in the experience of providers. It is the aim of this paper to review available current approaches to manage the major complications of sickle cell disease. We hope that this will establish another preliminary forum among providers that may eventually lead the way to better outcomes.

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