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Relevant topics are: Normal theory linear models, Inference and diagnostics for GLMs, Binomial regression, Poisson regression, Methods for handling overdispersion, Generalized estimating equations (GEEs).

These models include logistic regression and log-linear models for binomial and Poisson counts together with normal, gamma and inverse Gaussian models for continuous responses.

There were also several limitations to the abstracted data and the modeling framework. First, it is difficult to disentangle the independent contribution of each pathway. Although we abstracted data that accounted for the other potential pathways through adjustment in multivariable regression models or stratification wherever possible, the estimates of the contributions of each pathway may be confounded by other pathways. Second, development of the richest data source possible required approximations, with varying errors, when GMs and GSDs were not directly reported. For example, we assumed the median was approximately equivalent to the GM. In addition, we visually extracted medians from graphs in four of the seven studies of agricultural drift, which introduced imprecision in the estimates. Similarly, based on visual inspection of the data, we assumed a lognormal distribution for both the dust pesticide concentrations and the ratios. Deviations from this assumption could affect the point estimates, *p*-values and confidence intervals. As a result, we presented results only to 2 significant figures and we use confidence intervals and *p*-values as guides and not definitive measures of scientific significance.

There were several additional limitations to these analyses related to the coverage of the data and use of surrogates to represent these three exposure pathways. First, the magnitude of these differences may be overestimated due to publication bias because studies that observed no association between pesticide house dust levels and a particular pathway often did not report summary statistics or regression coefficients and could not be included here. Publication bias may account for differences in the contribution of the residential use pathway between the study and all other papers. The study included 74 of the 88 statistics and reported all possible comparisons between multiple pesticides and pest treatments, whereas other papers evaluating several pesticides generally reported only statistically significant findings. For the agricultural drift pathway, several studies stated that they did not observe an association between dust pesticide concentrations and distance from home to treated fields without providing the underlying summary statistics (; ; ). However, in these studies, the homes tended to be located very close to the fields, limiting the variability in distance categories. Second, as described above, the data were generally too sparse to identify whether differences in pesticide house dust concentrations varied by subgroups (e.g., pesticide type, crop type, application method, geographic location, or time period) and important distinctions may have been missed. Third, we used exposure surrogates to create our comparison groups; the exposure pathways may be better characterized with other metrics. For instance, compared to self-reported distance to treated fields, agricultural drift may be better captured using geographic information systems approaches that use satellite images, crop maps, historical farm records, and state pesticide use reporting databases to better classify exposure according to crop acreage or quantity of active ingredients applied near residences (; ; ; ; ; ); Fourth, most of the studies were based in the northwestern United States (Washington and Oregon) and Iowa, and thus the results may not be generalizable to populations in other geographic regions. Lastly, the lack of reporting of active ingredient-specific information in the published studies of the residential use treatments, and the resulting use of group-level probability-based weights from the NCI pesticide exposure matrix, introduces uncertainty in the quantification of the contribution of the residential use pathway. This pesticide exposure matrix was last updated with market and usage data from the year 2000 and may have limited relevance for informing residential use of certain pesticides subsequent to that year.

Similarly, prejudice, job promotions, competitive sports, and a host of other activates attempt to associate large qualitative differences with what are often minor quantitative differences, e.g., gold metal in Olympicswimming event may be milliseconds difference from no metal.

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Then if B places these successes at random points without replication, the probability that B will now get any given set of successes is exactly the same as the probability that A will see that set, no matter what the true probability of success happens to be.

**Power as a Function of Sample Size and Variance: **You should notice that what really made the difference in the size of is how much overlap there is in the two distributions.

Know that there is a simple connection between the numerical coefficients in the regression equation and the slope and intercept of regression line.

For example, the usual stepwise regression is often used for the selection of an appropriate subset of explanatory variables to use in model; however, it could be invalidated even by the presence of a few outliers.

However, for purposes of understanding the degree to which sample means will agree with the corresponding population mean, it is useful to consider what would happen if 10, or 50, or 100 separate sampling studies, of the same type, were conducted.

Sometimes however data mining is reminiscent of what happens when data has been collected and no significant results were found and hence an ad hoc, exploratory analysis is conducted to find a significant relationship.

It is generally not possible to state conditions under which the approximation given by the centrallimit theorem works and what sample sizes are needed before the approximation becomes goodenough.

It is well known that whatever the parent population is, the standardized variable will have adistribution with a mean 0 and standard deviation 1 under random sampling.

In MLR contexts, an interaction implies a change in the slope (of the regression of Y on X) from one value of W to another value of W (or, equivalently, a change in the slope of the regression of Y on W for different values of X): in a two-predictor regression with interaction, the response surface is not a plane but a twisted surface (like "a bent cookie tin", in Darlington's (1990) phrase).

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